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KMID : 1007520230320101445
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Food Science and Biotechnology
2023 Volume.32 No. 10 p.1445 ~ p.1452
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Rottlerin suppresses lipid accumulation by inhibiting de novo lipogenesis and adipogenesis via LRP6/mTOR/SREBP1C in 3T3-L1 adipocytes
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Kim Ye-Jin
Kim Hyun-Kyung
Kang Su-Min
Kim Ha-Yoon
Go Gwang-Woong
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Abstract
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Rottlerin is isolated from Mallotus japonicus, a plant rich in polyphenols. Rottlerin is a selective PKCδ-inhibitor and is also known as an uncoupler of oxidative phosphorylation and anti-neoplastic agent. However, its anti-obesity effect is yet to be established. Therefore, this study tested whether rottlerin inhibits adipogenesis and de novo lipogenesis via the LRP6/mTOR/SREBP1C pathway in 3T3-L1 adipocytes. Rottlerin dramatically decreased lipid accumulation assessed by Oil Red O as evidence to support the cellular phenotype (p?
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KEYWORD
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Rottlerin, Adipogenesis, De novo lipogenesis, 3T3-L1 adipocytes, The nutrient-sensing mTOR pathway
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